In vitro study of the effects of cadmium on the activation of the estrogen response element using the YES screen.
Identifieur interne : 000D51 ( Main/Exploration ); précédent : 000D50; suivant : 000D52In vitro study of the effects of cadmium on the activation of the estrogen response element using the YES screen.
Auteurs : Xavier Denier [France] ; Jérome Couteau ; Magalie Baudrimont ; Elisabeth M. Hill ; Jeanette Rotchell ; Christophe MinierSource :
- Marine environmental research [ 0141-1136 ] ; 2008.
Descripteurs français
- mix :
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Receptors, Estrogen.
- chemical , pharmacology : Cadmium, Water Pollutants, Chemical.
- drug effects : Yeasts.
- genetics : Response Elements, Yeasts.
- methods : Environmental Monitoring.
Abstract
Estrogenic potential of environmental samples is frequently assessed using receptor-based functional assays. Using the yeast estrogen screen (YES) developed by Routledge and Sumpter, we assessed the ability of cadmium to activate the estrogen receptor-mediated response. No induced transcriptional activity was observed with a range of CdCl2 concentrations (1 nm-1mM). But, when combining cadmium with the model compound 17beta-estradiol, cadmium was able to significantly potentiate the induced estrogenic response for concentrations ranging from 15 nM to 1 microM. A maximal effect was observed at 0.5 microM with a ten fold reduction of the 17beta-estradiol EC50.
Url:
DOI: 10.1016/j.marenvres.2008.02.038
PubMed: 18395789
Affiliations:
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Le document en format XML
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Hill</name></author><author><name sortKey="Rotchell, Jeanette" sort="Rotchell, Jeanette" uniqKey="Rotchell J" first="Jeanette" last="Rotchell">Jeanette Rotchell</name></author><author><name sortKey="Minier, Christophe" sort="Minier, Christophe" uniqKey="Minier C" first="Christophe" last="Minier">Christophe Minier</name></author></analytic><series><title level="j">Marine environmental research</title><idno type="ISSN">0141-1136</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cadmium (pharmacology)</term><term>Environmental Monitoring (methods)</term><term>Receptors, Estrogen (metabolism)</term><term>Response Elements (genetics)</term><term>Water Pollutants, Chemical (pharmacology)</term><term>Yeasts (drug effects)</term><term>Yeasts (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Estrogen</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cadmium</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Yeasts</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Response Elements</term><term>Yeasts</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Environmental Monitoring</term></keywords><keywords scheme="mix" xml:lang="fr"><term>Life Sciences</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Estrogenic potential of environmental samples is frequently assessed using receptor-based functional assays. Using the yeast estrogen screen (YES) developed by Routledge and Sumpter, we assessed the ability of cadmium to activate the estrogen receptor-mediated response. No induced transcriptional activity was observed with a range of CdCl2 concentrations (1 nm-1mM). But, when combining cadmium with the model compound 17beta-estradiol, cadmium was able to significantly potentiate the induced estrogenic response for concentrations ranging from 15 nM to 1 microM. A maximal effect was observed at 0.5 microM with a ten fold reduction of the 17beta-estradiol EC50.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Le Havre</li></settlement></list><tree><noCountry><name sortKey="Baudrimont, Magalie" sort="Baudrimont, Magalie" uniqKey="Baudrimont M" first="Magalie" last="Baudrimont">Magalie Baudrimont</name><name sortKey="Couteau, Jerome" sort="Couteau, Jerome" uniqKey="Couteau J" first="Jérome" last="Couteau">Jérome Couteau</name><name sortKey="Hill, Elisabeth M" sort="Hill, Elisabeth M" uniqKey="Hill E" first="Elisabeth M" last="Hill">Elisabeth M. Hill</name><name sortKey="Minier, Christophe" sort="Minier, Christophe" uniqKey="Minier C" first="Christophe" last="Minier">Christophe Minier</name><name sortKey="Rotchell, Jeanette" sort="Rotchell, Jeanette" uniqKey="Rotchell J" first="Jeanette" last="Rotchell">Jeanette Rotchell</name></noCountry><country name="France"><region name="Région Normandie"><name sortKey="Denier, Xavier" sort="Denier, Xavier" uniqKey="Denier X" first="Xavier" last="Denier">Xavier Denier</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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